By Marvin Jens

ISBN-10: 3319070819

ISBN-13: 9783319070810

ISBN-10: 3319070827

ISBN-13: 9783319070827

The paintings defined during this publication is a wonderful instance of interdisciplinary examine in structures biology. It indicates how strategies and techniques from the sector of physics might be successfully used to reply to organic questions and stories on a singular technique related to inventive computer-based analyses of high-throughput organic information. a few of the findings defined within the booklet, that are the results of collaborations among the writer (a theoretical scientist) and experimental biologists and among diverse laboratories, were released in fine quality peer-reviewed journals equivalent to Molecular telephone and Nature. even if, whereas these courses handle diverse points of post-transcriptional gene legislation, this ebook offers readers with a whole, coherent and logical view of the study venture as an entire. The advent offers post-transcriptional gene legislation from a special perspective, highlighting elements of knowledge conception and evolution and laying the foundation for the questions addressed within the next chapters, which difficulty the law of the transcriptome because the basic sensible provider of lively genetic information.

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Extra info for Dissecting Regulatory Interactions of RNA and Protein: Combining Computation and High-throughput Experiments in Systems Biology

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Sohn, Y. T. N. Kim, Molecular basis for the recognition of primary micrornas by the drosha-dgcr8 complex. Cell 125(5), 887–902 (2006) 40. B. D. B. B. L. J. Clark, J. Kjems, Mirna-dependent gene silencing involving ago2-mediated cleavage of a circular antisense rna. EMBO J. 30(21), 4414–4422 (2011) 41. B. I. H. B. Bramsen, B. K. Damgaard, J. Kjems, Natural RNA circles function as efficient microRNA sponges. Nature (2013) 42. L. Hofacker, W. F. S. Bonhoeffer, M. Tacker, P. Schuster, Fast folding and comparison of rna secondary structures.

M. Cesana, D. Cacchiarelli, I. Legnini, T. Santini, O. Sthandier, M. Chinappi, A. Tramontano, I. Bozzoni, A long noncoding rna controls muscle differentiation by functioning as a competing endogenous rna. Cell 147(2), 358–369 (2011) 16. W. C. Chan, A. Kuo, P. Leder, The mouse formin (fmn) gene: abundant circular rna transcripts and gene- targeted deletion analysis. Mol. Med. 4(9), 614–628 (1998) 17. Y. T. F. C. Huang, Lengthening of 3’ utr increases with morphological complexity in animal evolution.

H. T. S. P. Bartel, Mammalian micrornas predominantly act to decrease target mrna levels. Nature 466(7308), 835–840 (2010) 39. J. Han, Y. H. W. Nam, I. K. S. Sohn, Y. T. N. Kim, Molecular basis for the recognition of primary micrornas by the drosha-dgcr8 complex. Cell 125(5), 887–902 (2006) 40. B. D. B. B. L. J. Clark, J. Kjems, Mirna-dependent gene silencing involving ago2-mediated cleavage of a circular antisense rna. EMBO J. 30(21), 4414–4422 (2011) 41. B. I. H. B. Bramsen, B. K. Damgaard, J.

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Dissecting Regulatory Interactions of RNA and Protein: Combining Computation and High-throughput Experiments in Systems Biology by Marvin Jens


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