By Anthony H. Futerman
The quantity assembles present details at the function of ceramide as a signalling molecule in sixteen chapters written through best employees during this region. particular cognizance is given to mechanisms of study of ceramide and its biophysical homes, on enzymes of ceramide metabolism and down-stream objectives of ceramide, at the cross-talk of ceramide signalling with different signalling pathways, and at the function of ceramide in neuronal signalling. ultimately, the publication closes with a piece at the healing implications of ceramide motion, within the components of cannabinoid motion, chemotherapy, and atherosclerosis, and illustrates the capability scientific value of delineating the jobs of ceramide in mobile signalling. this can be the 1st quantity in particular dedicated to ceramide signalling, and may act as a useful source for uncomplicated and scientific researchers and graduate scholars wishing to get a state-of-the-art review of this speedily relocating box.
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Ceramide-Mediated Receptor Clustering 23 Figure 1. CD95 triggers translocation of the A-SMase onto the cell surface and clusters in membrane rafts. Stimulation via CD95 results in translocation of the A-SMase onto the cell surface and clustering of CD95. Surface A-SMase and clustered CD95 co-localize with FITC-cholera toxin indicating a clustering of CD95 in membrane rafts modified by the ASM. Cells were stimulated for 2 min via CD95, stained with FITCCholeratoxin, Cy3-labeled anti-CD95 and Cy5-coupled anti-A-SMase antibodies and analyzed by confocal microscopy.
Ceramide Signaling (Molecular Biology Intelligence Unit) by Anthony H. Futerman