By Anthony H. Futerman

ISBN-10: 0306474425

ISBN-13: 9780306474422

ISBN-10: 0585422966

ISBN-13: 9780585422961

The quantity assembles present details at the function of ceramide as a signalling molecule in sixteen chapters written through best employees during this region. particular cognizance is given to mechanisms of study of ceramide and its biophysical homes, on enzymes of ceramide metabolism and down-stream objectives of ceramide, at the cross-talk of ceramide signalling with different signalling pathways, and at the function of ceramide in neuronal signalling. ultimately, the publication closes with a piece at the healing implications of ceramide motion, within the components of cannabinoid motion, chemotherapy, and atherosclerosis, and illustrates the capability scientific value of delineating the jobs of ceramide in mobile signalling. this can be the 1st quantity in particular dedicated to ceramide signalling, and may act as a useful source for uncomplicated and scientific researchers and graduate scholars wishing to get a state-of-the-art review of this speedily relocating box.

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J Biol Chem 1998b; 273:2738-2746. 32. Liu P, Anderson RG. Compartmentalized production of ceramide at the cell surface. J Biol Chem 1995; 270:27179-27185. 33. Smart EJ, Graf GA, McNiven MA et al. Caveolins, liquid-ordered domains, and signal transduction. Mol Cell Biol 1999; 19:7289-7304. 34. Schissel SL, Tweedie-Hardman J, Rapp JH et al. Rabbit aorta and human atherosclerotic lesions hydrolyze the sphingomyelin of retained low-density lipoprotein. Proposed role for arterial-wall sphingomyelinase in subendothelial retention and aggregation of atherogenic lipoproteins.

9. Chao MV. Ceramide: a potential second messenger in the nervous system. Mol Cellular Neurosci 1995; 6:91-96. 10. Gómez-Muñoz A. Modulation of cell signalling by ceramides. Biochim Biophys Acta 1998; 1391:92-109. 11. Hannun YA. Functions of ceramide in coordinating cellular responses to stress. Science 1996; 274:1855-1859. 12. Kolesnick RN, Gõni FM, Alonso A. Compartmentalization of ceramide signaling: physical foundations and biological effects. J Cell Physiol 2000; 184:285-300. 13. Spiegel S, Foster D, Kolesnick R.

Ceramide-Mediated Receptor Clustering 23 Figure 1. CD95 triggers translocation of the A-SMase onto the cell surface and clusters in membrane rafts. Stimulation via CD95 results in translocation of the A-SMase onto the cell surface and clustering of CD95. Surface A-SMase and clustered CD95 co-localize with FITC-cholera toxin indicating a clustering of CD95 in membrane rafts modified by the ASM. Cells were stimulated for 2 min via CD95, stained with FITCCholeratoxin, Cy3-labeled anti-CD95 and Cy5-coupled anti-A-SMase antibodies and analyzed by confocal microscopy.

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Ceramide Signaling (Molecular Biology Intelligence Unit) by Anthony H. Futerman

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