By R. Süss, V. Kinzel, J. D. Scribner (auth.)

ISBN-10: 038790042X

ISBN-13: 9780387900421

ISBN-10: 1461298415

ISBN-13: 9781461298410

This e-book quite should be learn on holiday, only for leisure. Granted, melanoma is, actually, a dangerous critical subject, and melanoma examine is basically part of medication with Hippocrates in its again­ floor. but, melanoma study is usually usual technology, and as such it yields the thrill and sorrows of any technological know-how. The melanoma challenge can be a mind teaser, a problem for the curious. This introductory document on experimental melanoma examine is there­ fore directed to curious scholars of many disciplines: certainly to clinical scholars, but in addition to chemists and physicists who've an curiosity in organic phenomena; biology scholars would definitely en­ counter pr9blems odd to their box in what's supposedly a medi­ cal one. we've got tried to write down with no assumptions to a definite measure, for a chemist is largely in over his head in medication, and a doctor has purely the slightest concept of the chemical difficulties im­ portant in melanoma learn. We had no goal of giving an entire view of the sphere, and from the big variety of assorted strains of improvement we've got selected just a couple of. Chemotherapy, as an ex­ abundant, has been handled relatively cursorily, besides RNA tumor viruses, even though it is feasible that simply those topics are specially very important for human tumors. Tumor induction through radiation may merely be pointed out in passing, even with its nice sensible value; equally the function of hormones was once in basic terms intimated.

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MAB was known to be inactive in this reaction. However, the N-hydroxy derivative seemed a likely possibility, since such derivatives had been found from metabolism of all the other amines studied. Unfortunately, N-OH-MAB was not available, but its benzoate ester (IV) was in hand. In actual fact, it was enough to simply mix N-benzoyloxy-MAB and methionine, followed by treatment with cold alkali, to obtain 3-CHaS-MAB. If one waited long enough (4 hours), even the alkali was unnecessary. In no case was an enzyme required for the reaction.

This experiment showed clearly that at least ,B-naphthylamine does not act directly to produce tumors. We must assume that somewhere in the organism there is a transformation into an active form. After feeding, the amine passes through numerous organs, with many opportunities to be converted chemically. Thus, it is understandable that ,B-naphthylamine is carcinogenic on feeding, but inactive on direct implantation into the bladder. It was quite natural that interest in many laboratories centered on the metabolic products formed in organisms from aromatic amines.

2-Acetylaminofluorene is really an amide (of acetic acid). We will see, however, that it logically is in the same class as the aromatic amines already mentioned. We have now mentioned the most important representatives of these amines: ,B-naphthylamine, the azo dyes, and aminofluorenes. Let us now consider these substances more closely, in particular, let us become acquainted with their behavior in metabolism. 25 Not all Aminoazo Dyes are Carcinogenic By no means are all aminoazo dyes carcinogenic.

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Cancer: Experiments and Concepts by R. Süss, V. Kinzel, J. D. Scribner (auth.)


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