By Lester Packer

ISBN-10: 0585343012

ISBN-13: 9780585343013

ISBN-10: 0824796543

ISBN-13: 9780824796549

This distinct, cutting-edge reference offers an in depth account of the molecular mechanisms underlying the a number of features of biothiols-emphasizing the organic and scientific implications of interactions among oxidants and biothiols.

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Extra resources for Biothiols in Health and Disease (Antioxidants in Health and Disease Series, 2)

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43:595611. 7. Wardman, P. (1988) Conjugation and oxidation of glutathione via thiyl free radicals. In: Glutathione Conjugation. ), pp. 4372, Academic Press, London. 8. Prütz, W. , and Land, E. J. (1994) The glutathione free radical equilibrium, GS· + GS- = GSSG·-, mediating electron transfer to Fe(III)-cytochrome c. Biophys. Chem. 49: 101111. 9. , and von Sonntag, C. (1994) Pulse radiolysis of 2-mercaptoethanol in oxygenated aqueous solution. Generation and reactions of the thiylperoxyl radical.

And Hunter, E. P. L. (1986) Reaction mechanisms of peroxyl and C-centered radicals with sulfhydryls. J. Free Radicals Biol. Med. 2:227230. 45. Newton, G. , Dwyer, T. , Ward, J. , and Fahey, R. C. (1992) Determination of the acid dissociation constants for WR-1065 by proton NMR spectroscopy. Radiat. Res. 131:143151. 46. Everett, S. , Folkes, L. -D. (1994) Free-radical repair by a novel perthiol: reversible hydrogen transfer and perthiyl radical formation. Free Radical Res. 20:387400. 47. , and Blake, D.

Thiyl radicals conjugated with thiolate, as in Eq. (3) to form disulfide radical-anions, react with oxygen by electron transfer at rates approaching the diffusion-controlled limit. 1 × 108 dm3 mol-1 s-1 for RSH = GSH has been reported (8): Since, as noted above and discussed elsewhere (2), the relaxation time for Eq. (3) is a few microseconds or less under typical physiological conditions, the conjugation equilibrium will usually not be rate-limiting. The half-life for Eq. (21) (= (ln 2)/k21[02]) is about 3040 µs in well-oxygenated tissue and about an order of magnitude longer in hypoxic cells.

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Biothiols in Health and Disease (Antioxidants in Health and Disease Series, 2) by Lester Packer


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