By Yin-Tak Woo, David Y. Lai, Joseph C. Arcos
Chemical Induction of melanoma: Structural Bases and organic Mechanisms, quantity IIIB: Aliphatic and Polyhalogenated cancer agents covers environmentally and occupationally major cancer causing agents of commercial origins.
The ebook discusses the structure-activity relationships, metabolism, and environmental importance of the halogenated linear alkanes and alkenes and the halogenated cycloalkanes; and cycloalkene insecticides, biphenyls, and comparable aromatics. The textual content additionally describes the structure-activity relationships, metabolism, and environmental value of the halogenated phenoxy acids, fragrant ethers, dibenzofurans, and dibenzo-p-dioxins; and ethylene glycol, diethylene glycol, dioxane, and similar compounds. The structure-activity relationships, metabolism, and environmental value of phenols and phenolic compounds; nitroalkanes and nitroalkenes; and acetamide, dimethylcarbamyl chloride, and comparable compounds thiocarbonyl compounds also are encompassed. The publication extra tackles the structure-activity relationships, metabolism, and environmental importance if fatty acids, detergents, and different surfactants with oncogenic power. The textual content then seems to be into the impression of chemical reactivity, molecular geometry, and metabolism on carcinogenic job.
Chemists, geneticists, and people considering melanoma study will locate the booklet beneficial.
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Extra info for Aliphatic and Polyhalogenated Carcinogens. Structural Bases and Biological Mechanisms
Considered inconclusive because of i n s u f f i c i e n t l y high dose (below maximal tolerated dose) or because inadequate number of mice survived long enough to be a t r i s k from late-developing tumors. Also carcinogenic in the r a t . Summarized from National Cancer I n s t i t u t e / N a t i o n a l Toxicology Program Carcinogenesis Technical Reports No. 2, 3, 13, 27, 28, 55, 66, 73, 74, 86, 106, 110, and 228. p. administration. Induced stomach tumors after oral administration. Also inactive by oral administration.
0 ppm (213). However, this finding was not confirmed by Culik et al. 2 Organohalogens, H-Bond Reactors, Surfactant Types who failed to observe significant teratogenic effects in rats exposed to up to 25 ppm of the compound. 3. 1. Carcinogenicity and Structure-Activity Relationships OVERVIEW Since the discovery of the carcinogenicity of carbon tetrachloride and chloroform in the early 1940s, some 40-50 haloalkanes and haloalkenes have been tested for carcinogenic activity. Actually, many of these studies were conducted in more recent years in response to the concern that arose from the potent carcinogenicity of vinyl chloride in humans.
The strain used in this study was Fischer 344; the daily dosages were 75 and 150 mg/kg. Halothane (l,l,l-trifluoro-2-bromo-2-chloroethane), an anesthetic agent, has been suspected for some time to be carcinogenic. This compound has been tested by Eger et al. (266). Perinatal exposures of Swiss ICR mice to 1/32, 1/8, and 1/2 maximum allowable concentrations (MAC) of halothane 2 h/day on days 11, 13, 15, and 17 of gestation and 2 h/day, 3 days/week for 8 weeks post-partum elicited no significant carcinogenic effects.
Aliphatic and Polyhalogenated Carcinogens. Structural Bases and Biological Mechanisms by Yin-Tak Woo, David Y. Lai, Joseph C. Arcos